H2AFY

1U35, 1ZR3, 1ZR5, 2F8N, 2FXK, 3HQH, 3HSV, 3IID, 3IIF, 3IVB, 5IIT955526914ENSG00000113648ENSMUSG00000015937O75367Q9QZQ8NM_001040158NM_004893NM_138609NM_138610NM_001159513NM_001159514NM_001159515NM_012015NP_001035248NP_004884NP_613075NP_613258NP_001152985NP_001152986NP_001152987NP_036145Core histone macro-H2A.1 is a protein that in humans is encoded by the H2AFY gene.1u35: Crystal structure of the nucleosome core particle containing the histone domain of macroH2A1yd9: 1.6A Crystal Structure of the Non-Histone Domain of the Histone Variant MacroH2A1.1.1zr3: Crystal structure of the macro-domain of human core histone variant macroH2A1.1 (form B)1zr5: Crystal structure of the macro-domain of human core histone variant macroH2A1.22f8n: 2.9 Angstrom X-ray structure of hybrid macroH2A nucleosomes2fxk: Crystal structure of the macro-domain of human core histone variant macroH2A1.1 (form A) Core histone macro-H2A.1 is a protein that in humans is encoded by the H2AFY gene. Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene encodes a member of the histone H2A family. It replaces conventional H2A histones in a subset of nucleosomes where it represses transcription and participates in stable X chromosome inactivation. Alternative splicing results in multiple transcript variants encoding different isoforms. Expression of these isoforms is associated to several cancers, such as hepatocellular carcinoma.