Caldesmon

800n/aENSG00000122786n/aQ05682n/aNM_004342NM_033138NM_033139NM_033140NM_033157n/aNP_004333NP_149129NP_149130NP_149131NP_149347n/aCaldesmon is a protein that in humans is encoded by the CALD1 gene. Caldesmon is a protein that in humans is encoded by the CALD1 gene. Caldesmon is a calmodulin binding protein. Like calponin, caldesmon tonically inhibits the ATPase activity of myosin in smooth muscle. This gene encodes a calmodulin- and actin-binding protein that plays an essential role in the regulation of smooth muscle and nonmuscle contraction. The conserved domain of this protein possesses the binding activities to Ca++-calmodulin, actin, tropomyosin, myosin, and phospholipids. This protein is a potent inhibitor of the actin-tropomyosin activated myosin MgATPase, and serves as a mediating factor for Ca++-dependent inhibition of smooth muscle contraction. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. In diagnostic immunochemistry, caldesmon is a marker for smooth muscle differentiation.