Sivelestat

Sivelestat (INN, research name ONO 5046, marketed as Elaspol) is an inhibitor of human neutrophil elastase. Sivelestat (INN, research name ONO 5046, marketed as Elaspol) is an inhibitor of human neutrophil elastase. It is used in the treatment of acute respiratory failure and preliminary studies show it may also improve neuropathic pain. Sivelestat is synthesised as follows: