IKZF3

2280622780ENSG00000161405ENSMUSG00000018168Q9UKT9O08900NM_001257412NM_001257413NM_001257414NM_001284514NM_001284515NM_001284516NM_012481NM_183228NM_183229NM_183230NM_183231NM_011771NP_001244342NP_001244343NP_001271443NP_001271444NP_001271445NP_036613NP_899051NP_899052NP_899053NP_899054NP_899055NP_035901Zinc finger protein Aiolos also known as Ikaros family zinc finger protein 3 is a protein that in humans is encoded by the IKZF3 gene. Zinc finger protein Aiolos also known as Ikaros family zinc finger protein 3 is a protein that in humans is encoded by the IKZF3 gene. This gene encodes a member of the Ikaros family of zinc-finger proteins. Three members of this protein family (Ikaros, Aiolos and Helios) are hematopoietic-specific transcription factors involved in the regulation of lymphocyte development. This gene product is a transcription factor that is important in the regulation of B lymphocyte proliferation and differentiation. Both Ikaros and Aiolos can participate in chromatin remodeling. Regulation of gene expression in B lymphocytes by Aiolos is complex as it appears to require the sequential formation of Ikaros homodimers, Ikaros/Aiolos heterodimers, and Aiolos homodimers. At least six alternative transcripts encoding different isoforms have been described. IKZF3 has been shown to interact with BCL2-like 1 and HRAS. This article incorporates text from the United States National Library of Medicine, which is in the public domain.