Myeloblastin

Myeloblastin (EC 3.4.21.76, leukocyte proteinase 3, leukocyte proteinase 4, Wegener's granulomatosis autoantigen, proteinase PR-3, proteinase-3, PMNL proteinase) is an enzyme. This enzyme catalyses the following chemical reaction: Hydrolysis of proteins, including elastin, by preferential cleavage: -Ala- > -Val- Myeloblastin (EC 3.4.21.76, leukocyte proteinase 3, leukocyte proteinase 4, Wegener's granulomatosis autoantigen, proteinase PR-3, proteinase-3, PMNL proteinase) is an enzyme. This enzyme catalyses the following chemical reaction: Hydrolysis of proteins, including elastin, by preferential cleavage: -Ala- > -Val- This enzyme is present in polymorphonuclear leukocyte granules. Downregulation of myeloblastin in promyelocytic leukemia cells was shown to induce their growth arrest and differentiation.