Ifi202

Ifi202 is a mouse gene (encodes for the p202 protein). Increased expression levels of the Ifi202 mRNA and nuclear localization of p202 protein in immune cells are associated with the development of autoimmunity in certain strains of mice. Therefore, the gene has been implicated in the development of systemic lupus erythematosus (SLE). SLE is a systemic autoimmune disease responsible for attacking many types of organs. Ifi202 gene encodes for p202 protein, which belongs to the p200-protein family. The IFI family of genes is inducible by type 1 interferon and interferon gamma. Ifi202 is a mouse gene (encodes for the p202 protein). Increased expression levels of the Ifi202 mRNA and nuclear localization of p202 protein in immune cells are associated with the development of autoimmunity in certain strains of mice. Therefore, the gene has been implicated in the development of systemic lupus erythematosus (SLE). SLE is a systemic autoimmune disease responsible for attacking many types of organs. Ifi202 gene encodes for p202 protein, which belongs to the p200-protein family. The IFI family of genes is inducible by type 1 interferon and interferon gamma. The relationship between increased ifi202 expression and SLE was first suggested by Rozzo et al. in 2001. It was discovered due to the over-expression of p202 in splenic B cells of mice showing similar symptoms as lupus. Currently the prototypical mouse model for SLE is (NZWxNZB)F1, which is short for the first generation offspring of New Zealand Black and New Zealand White mice. The overproduction of p202 seems to lead to the suppression of p53 protein, which is a regulatory protein in the process of apoptosis. This is hypothesized to contribute to some of the symptoms of SLE.