Calsenilin

2E6W3081856461ENSG00000115041ENSMUSG00000079056Q9Y2W7Q9QXT8P0C092NM_001034914NM_013434NM_001111331NM_001291005NM_019789NP_001030086NP_038462NP_001104801NP_001277934NP_062763Calsenilin is a protein that in humans is encoded by the KCNIP3 gene. Calsenilin is a protein that in humans is encoded by the KCNIP3 gene. This gene encodes a member of the family of voltage-gated potassium (Kv) channel-interacting proteins, which belong to the neuronal calcium sensor family of proteins. Members of this family are small calcium binding proteins containing EF-hand-like domains. They are integral subunit components of native Kv4 channel complexes that may regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium. The encoded protein also functions as a calcium-regulated transcriptional repressor, and interacts with presenilins. In addition, the protein has been shown to transcriptionally repress A20 (TNFAIP3) expression and thus modulate the anti-inflammatory signaling. Alternatively spliced transcript variants encoding different isoforms have been described. Calsenilin has been shown to interact with PSEN1 and PSEN2. This article incorporates text from the United States National Library of Medicine, which is in the public domain.