VWA2

340706240675ENSG00000165816ENSMUSG00000025082Q5GFL6Q70UZ7NM_001272046NM_198496NM_001320804NM_172840NP_001258975NP_001307733NP_766428von Willebrand factor A domain-containing protein 2, also known as A domain-containing protein similar to matrilin and collagen (AMACO) is a protein that in humans is encoded by the VWA2 gene. von Willebrand factor A domain-containing protein 2, also known as A domain-containing protein similar to matrilin and collagen (AMACO) is a protein that in humans is encoded by the VWA2 gene. AMACO is a member of the von Willebrand factor A-like (VWA) domain containing protein superfamily and consists of three VWA-like domains, two EGF-like domains, a cysteine-rich domain and a unique C-terminal domain.AMACO is an extracellular matrix protein and mostly deposited adjacent to basement membranes. AMACO binds directly to FRAS1 which is part of the Fraser complex important for epithelial-connective tissue interaction, the exact biological role of AMACO, however, is still unknown. In 2005 AMACO was found markedly induced in colon cancers ; indicating that it might be a good candidate as a biomarker for this type of cancer.