PKMYT1

3P1A9088268930ENSG00000127564ENSMUSG00000023908Q99640Q0IJ49Q9ESG9NM_001258450NM_001258451NM_004203NM_182687NM_023058NP_001245379NP_001245380NP_004194NP_872629NP_004194.3NP_075545Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase is an enzyme that in humans is encoded by the PKMYT1 gene. Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase is an enzyme that in humans is encoded by the PKMYT1 gene. The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase preferentially phosphorylates and inactivates cyclin-dependent kinase 1 (CDK1), and thus negatively regulates cell cycle G2/M transition. This kinase is associated with the membrane throughout the cell cycle. Its activity is highly regulated during the cell cycle. Protein kinases AKT1/PKB and PLK (Polo-like kinase) have been shown to phosphorylate and regulate the activity of this kinase. Alternatively spliced transcript variants encoding distinct isoforms have been reported. PKMYT1 has been shown to interact with PIN1 and STEAP3.