Enolase 2

1TE6, 2AKM, 2AKZ, 3UCC, 3UCD, 3UJE, 3UJF, 3UJR, 3UJS, 4ZCW, 4ZA0202613807ENSG00000111674ENSMUSG00000004267P09104Q6FHV6P17183NM_001975NM_013509NM_001302642NM_001355220NP_001966NP_001966.1NP_001289571NP_038537NP_001342149Gamma-enolase, also known as enolase 2 (ENO2) or neuron specific enolase (NSE), is an enzyme that in humans is encoded by the ENO2 gene. Gamma-enolase is a phosphopyruvate hydratase.1te6: Crystal Structure of Human Neuron Specific Enolase at 1.8 angstrom2akm: Fluoride Inhibition of Enolase: Crystal Structure of the Inhibitory Complex2akz: Fluoride Inhibition of Enolase: Crystal Structure of the Inhibitory Complex Gamma-enolase, also known as enolase 2 (ENO2) or neuron specific enolase (NSE), is an enzyme that in humans is encoded by the ENO2 gene. Gamma-enolase is a phosphopyruvate hydratase. Gamma-enolase is one of the three enolase isoenzymes found in mammals. This isoenzyme, a homodimer, is found in mature neurons and cells of neuronal origin. A switch from alpha enolase to gamma enolase occurs in neural tissue during development in rats and primates. Click on genes, proteins and metabolites below to link to respective articles. Detection of NSE with antibodies can be used to identify neuronal cells and cells with neuroendocrine differentiation. NSE is produced by small-cell carcinomas, which are neuroendocrine in origin. NSE is therefore a useful tumor marker for distinguishing small-cell carcinomas from other tumors.