The Conserved oligomeric Golgi complex (COG) is a multiprotein complex found in the Golgi apparatus structure and involved in intracellular transport and glycoprotein modification. The Conserved oligomeric Golgi complex (COG) is a multiprotein complex found in the Golgi apparatus structure and involved in intracellular transport and glycoprotein modification. Earlier names for this complex were : the Golgi transport complex (GTC), the LDLC complex, which is involved in glycosylation reactions, and the SEC34 complex, which is involved in vesicular transport. These 3 complexes are identical and have been termed the conserved oligomeric Golgi (COG) complex (Ungar et al., 2002). The COG protein complex consists of eight subunits, in two lobes; Lobe A consists of COG1, COG2, COG3, COG4 and lobe B consists of COG5, COG6, COG7, COG8. The conserved oligomeric Golgi complex plays important roles in maintaining the structure and transport mechanisms within the Golgi apparatus.