Parathyroid hormone-related peptide

Parathyroid hormone-related protein (or PTHrP) is a protein member of the parathyroid hormone family. It is occasionally secreted by cancer cells (breast cancer, certain types of lung cancer including squamous cell lung carcinoma). However, it also has normal functions.3H3G, 1BZG, 1M5N, 3FFD574419227ENSG00000087494ENSMUSG00000048776P12272P22858NM_002820NM_198964NM_198965NM_198966NM_008970NP_002811NP_945315NP_945316NP_945317n/aPTHrP acts as an endocrine, autocrine, paracrine, and intracrine hormone. It regulates endochondral bone development by maintaining the endochondral growth plate at a constant width. It also regulates epithelial-mesenchymal interactions during the formation of the mammary glands. Four alternatively spliced transcript variants encoding two distinct isoforms have been observed. There is also evidence for alternative translation initiation from non-AUG (CUG and GUG) start sites, in-frame and downstream of the initiator AUG codon, to give rise to nuclear forms of this hormone.The protein was first isolated in 1987 by T.J. Martin's team at the University of Melbourne. Miao et al. showed that disruption of the PTHrP gene in mice caused a lethal phenotype and distinct bone abnormalities, suggesting that PTHrP has a physiological function.Parathyroid hormone-related protein has been shown to interact with KPNB1 and Arrestin beta 1.This article incorporates text from the United States National Library of Medicine, which is in the public domain.