Jingzhaotoxin

Jingzhaotoxin proteins are part of a venom secreted by Chilobrachys jingzhao, the Chinese tarantula. and act as neurotoxins. There are several subtypes of jingzhaotoxin, which differ in terms of channel selectivity and modification characteristics. All subspecies act as gating modifiers of sodium channels and/or, to a lesser extent, potassium channels. Jingzhaotoxin proteins are part of a venom secreted by Chilobrachys jingzhao, the Chinese tarantula. and act as neurotoxins. There are several subtypes of jingzhaotoxin, which differ in terms of channel selectivity and modification characteristics. All subspecies act as gating modifiers of sodium channels and/or, to a lesser extent, potassium channels. Chilobrachys jingzhao, also known as the Chinese earth tiger tarantula or Chilobrachys guangxiensis, can be found in China and Asia. This large tarantula belongs to the family of Theraphosidae. Jingzhaotoxins reported on this page are 29-36-residue polypeptides with varying numbers of stabilizing disulfide bridges. Jingzhaotoxins can target multiple channels. The following IC50 values have been determined: '*' Only a dissociation constant (Kd) was measured. Kd; 0.43 µM '**' Only a Kd was measured. Kd; 1.28 µM '***' Only a Kd was measured. Kd; 0.74 µM Effect on voltage-gated sodium channels (VGSC) JZTX-I preferentially acts on cardiac sodium channels, but also affects tetrodotoxin-sensitive (TTX-S) voltage-gated sodium channels (VGSC) in dorsal root ganglion (DRG) neurons. It modifies the sodium current by inhibiting channel inactivation and speeding up recovery after inactivation. JZTX-I does not affect the activation threshold of sodium channels.