PBRM1

3G0J, 3HMF, 3IU5, 3IU6, 3K2J, 3LJW, 3MB4, 3TLP, 4Q0N, 4Q0O, 4Y03, 5IID, 5FH7, 5II1, 5II2, 5FH6, 5FH85519366923ENSG00000163939ENSMUSG00000042323Q86U86Q8BSQ9NM_001350075NM_001350076NM_001350077NM_001350078NM_001350079NM_001366070NM_001366071NM_001366072NM_001366073NM_001366074NM_001366075NM_001366076NM_001359857NM_001359858NP_001337006NP_001337007NP_001337008NP_001352999NP_001353000NP_001353001NP_001353002NP_001353003NP_001353004NP_001353005NP_001346787Protein polybromo-1 (PB1) also known as BRG1-associated factor 180 (BAF180) is a protein that in humans is encoded by the PBRM1 gene.1w4s: CRYSTAL STRUCTURE OF THE PROXIMAL BAH DOMAIN OF POLYBROMO Protein polybromo-1 (PB1) also known as BRG1-associated factor 180 (BAF180) is a protein that in humans is encoded by the PBRM1 gene. Component of the SWI/SNF-B (PBAF) chromatin-remodeling complex, which contains at least SMARCA4/BRG1, SMARCB1/SNF5/INI1/BAF47, ACTL6A/BAF53A or ACTL6B/BAF53B, SMARCE1/BAF57, SMARCD1/BAF60A, SMARCD2/BAF60B, and actin. Chicken PB1 possesses 5 bromodomains, 2 bromo-adjacent homology (BAH) domains, and 1 truncated high-mobility group (HMG) motif. cPB1 is also homologous to yeast Rsc1, Rsc2, and Rsc4, essential proteins that are required for cell cycle progression through mitosis. PBRM1 is a tumor suppressor gene in many cancer subtypes. Mutations are especially prevalent in clear cell renal cell carcinoma.