NMNAT1

Nicotinamide mononucleotide adenylyltransferase 1 is an enzyme that in humans is encoded by the NMNAT1 gene. It is a member of the nicotinamide-nucleotide adenylyltransferases.1GZU, 1KKU, 1KQN, 1KQO, 1KR26480266454ENSG00000173614ENSMUSG00000028992Q9HAN9Q9EPA7NM_001297778NM_001297779NM_022787NM_133435NM_001356357NP_001284707NP_001284708NP_073624NP_597679NP_001343286The coenzyme NAD and its derivatives are involved in hundreds of metabolic redox reactions and are utilized in protein ADP-ribosylation, histone deacetylation, and in some Ca2+ signaling pathways. NMNAT (EC 2.7.7.1) is a central enzyme in NAD biosynthesis, catalyzing the condensation of nicotinamide mononucleotide (NMN) or nicotinic acid mononucleotide (NaMN) with the AMP moiety of ATP to form NAD or NaAD.Mutations in this gene have been shown associated to retinal degeneration pathologies, like Leber's congenital amaurosis.