The egg cell, or ovum (plural ova), is the female reproductive cell (gamete) in oogamous organisms. The egg cell is typically not capable of active movement, and it is much larger (visible to the naked eye) than the motile sperm cells. When egg and sperm fuse, a diploid cell (the zygote) is formed, which rapidly grows into a new organism. The egg cell, or ovum (plural ova), is the female reproductive cell (gamete) in oogamous organisms. The egg cell is typically not capable of active movement, and it is much larger (visible to the naked eye) than the motile sperm cells. When egg and sperm fuse, a diploid cell (the zygote) is formed, which rapidly grows into a new organism. While the non-mammalian animal egg was obvious, the doctrine ex ovo omne vivum ('every living an egg'), associated with William Harvey (1578–1657), was a rejection of spontaneous generation and preformationism as well as a bold assumption that mammals also reproduced via eggs. Karl Ernst von Baer discovered the mammalian ovum in 1827. The fusion of spermatozoa with ova (of a starfish) was observed by Oskar Hertwig in 1876. In animals, egg cells are also known as ova (singular ovum, from the Latin word ovum meaning egg or egg cell). The term ovule in animals is used for the young ovum of an animal. In vertebrates, ova are produced by female gonads (sexual glands) called ovaries. A number of ova are present at birth in mammals and mature via oogenesis. White et al. disproved the longstanding dogma that all of the ova are produced before birth. The team from the Vincent Center for Reproductive Biology, Massachusetts, Boston showed that oocyte formation takes place in ovaries of reproductive-age women. This report challenged a fundamental belief, held since the 1950s, that female mammals are born with a finite supply of eggs that is depleted throughout life and exhausted at menopause. In all mammals the ovum is fertilized inside the female body. The human ova grow from primitive germ cells that are embedded in the substance of the ovaries. Each of them divides repeatedly to give secretions of the uterine glands, ultimately forming a blastocyst. The ovum is one of the largest cells in the human body, typically visible to the naked eye without the aid of a microscope or other magnification device. The human ovum measures approximately 0.1 mm in diameter. Ooplasm (also: oöplasm) is the yolk of the ovum, a cell substance at its center, which contains its nucleus, named the germinal vesicle, and the nucleolus, called the germinal spot. The ooplasm consists of the cytoplasm of the ordinary animal cell with its spongioplasm and hyaloplasm, often called the formative yolk; and the nutritive yolk or deutoplasm, made of rounded granules of fatty and albuminoid substances imbedded in the cytoplasm. Mammalian ova contain only a tiny amount of the nutritive yolk, for nourishing the embryo in the early stages of its development only. In contrast, bird eggs contain enough to supply the chick with nutriment throughout the whole period of incubation.