FTH1

1FHA, 2CEI, 2CHI, 2CIH, 2CLU, 2CN6, 2CN7, 2FHA, 2IU2, 2Z6M, 3AJO, 3AJP, 3AJQ, 3ERZ, 3ES3, 4DYX, 4DYY, 4DYZ, 4DZ0, 4OYN, 4Y08, 4YKH, 4ZJK, 5CMQ, 5CMR249514319ENSG00000167996ENSMUSG00000024661P02794P09528NM_002032NM_010239NP_002023NP_034369Ferritin heavy chain is a ferroxidase enzyme that in humans is encoded by the FTH1 gene.1fha: SOLVING THE STRUCTURE OF HUMAN H FERRITIN BY GENETICALLY ENGINEERING INTERMOLECULAR CRYSTAL CONTACTS2cei: RECOMBINANT HUMAN H FERRITIN, K86Q MUTANT, SOAKED WITH ZN2chi: RECOMBINANT HUMAN H FERRITIN, K86Q AND E27D MUTANT2cih: RECOMBINANT HUMAN H FERRITIN, K86Q AND E27D MUTANT, SOAKED WITH ZN2clu: RECOMBINANT HUMAN H FERRITIN, K86Q AND E107D MUTANT2cn6: RECOMBINANT HUMAN H FERRITIN, K86Q AND E107D MUTANT, SOAKED WITH ZN IONS2cn7: RECOMBINANT HUMAN H FERRITIN, K86Q, E27D AND E107D MUTANT2fha: HUMAN H CHAIN FERRITIN2iu2: RECOMBINANT HUMAN H FERRITIN, K86Q, E27D AND E107D MUTANT, SOAKED WITH ZN IONS Ferritin heavy chain is a ferroxidase enzyme that in humans is encoded by the FTH1 gene. This gene encodes the heavy subunit of ferritin, the major intracellular iron storage protein in prokaryotes and eukaryotes. It is composed of 24 subunits of the heavy and light ferritin chains. Variation in ferritin subunit composition may affect the rates of iron uptake and release in different tissues. A major function of ferritin is the storage of iron in a soluble and nontoxic state. Defects in ferritin proteins are associated with several neurodegenerative diseases. This gene has multiple pseudogenes. Several alternatively spliced transcript variants have been observed, but their biological validity has not been determined. FTH1 has been shown to interact with Ferritin light chain. This article incorporates text from the United States National Library of Medicine, which is in the public domain.