MMP16

1RM8432517389ENSG00000156103ENSMUSG00000028226P51512Q9WTR0NM_005941NM_022564NM_032297NM_019724NP_005932NP_062698Matrix metalloproteinase-16 is an enzyme that in humans is encoded by the MMP16 gene.1rm8: Crystal structure of the catalytic domain of MMP-16/MT3-MMP: Characterization of MT-MMP specific features Matrix metalloproteinase-16 is an enzyme that in humans is encoded by the MMP16 gene. Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. This gene produces at least two transcripts, one which encodes a membrane-bound form and another a soluble form of the protein. Both forms of the protein activate MMP2 by cleavage. This gene was once referred to as MT-MMP2, but was renamed as MT-MMP3 or MMP16.