VAMP2

3FIE, 3FII, 3RK2, 3RK3, 3RL0684422318ENSG00000220205ENSMUSG00000020894P63027P63044NM_014232NM_001330125NM_009497NP_001317054NP_055047NP_033523Vesicle-associated membrane protein 2 is a protein that in humans is encoded by the VAMP2 gene.1kil: Three-dimensional structure of the complexin/SNARE complex1n7s: High Resolution Structure of a Truncated Neuronal SNARE Complex1sfc: NEURONAL SYNAPTIC FUSION COMPLEX Vesicle-associated membrane protein 2 is a protein that in humans is encoded by the VAMP2 gene. Synaptobrevins/VAMPs, syntaxins, and the 25-kD synaptosomal-associated protein SNAP25 are the main components of a protein complex involved in the docking and/or fusion of synaptic vesicles with the presynaptic membrane. VAMP2 is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family. VAMP2 is thought to participate in neurotransmitter release at a step between docking and fusion. Mice lacking functional synaptobrevin2/VAMP2 gene cannot survive after birth, and have a dramatically reduced synaptic transmission, around 10% of control. The protein forms a stable complex with syntaxin, synaptosomal-associated protein, 25 kD, and complexin. It also forms a distinct complex with synaptophysin. VAMP2 is a likely candidate gene for familial infantile myasthenia (FIMG) because of its map location and because it encodes a synaptic vesicle protein of the type that has been implicated in the pathogenesis of FIMG. VAMP2 has been shown to interact with: