SIAH2

5H9M647820439ENSG00000181788ENSMUSG00000036432O43255Q06986NM_005067NM_009174NP_005058NP_033200E3 ubiquitin-protein ligase SIAH2 is an enzyme that in humans is encoded by the SIAH2 gene. E3 ubiquitin-protein ligase SIAH2 is an enzyme that in humans is encoded by the SIAH2 gene. This gene encodes a protein that is a member of the seven in absentia homolog (SIAH) family. The protein is an E3 ligase and is involved in ubiquitination and proteasome-mediated degradation of specific proteins. The activity of this ubiquitin ligase has been implicated in regulating cellular response to hypoxia. SIAH2 has been shown to interact with PEG10, Synaptophysin, PEG3 and VAV1.