Pesticide application refers to the practical way in which pesticides, (including herbicides, fungicides, insecticides, or nematode control agents) are delivered to their biological targets (e.g. pest organism, crop or other plant). Public concern about the use of pesticides has highlighted the need to make this process as efficient as possible, in order to minimise their release into the environment and human exposure (including operators, bystanders and consumers of produce). The practice of pest management by the rational application of pesticides is supremely multi-disciplinary, combining many aspects of biology and chemistry with: agronomy, engineering, meteorology, socio-economics and public health, together with newer disciplines such as biotechnology and information science. Pesticide application refers to the practical way in which pesticides, (including herbicides, fungicides, insecticides, or nematode control agents) are delivered to their biological targets (e.g. pest organism, crop or other plant). Public concern about the use of pesticides has highlighted the need to make this process as efficient as possible, in order to minimise their release into the environment and human exposure (including operators, bystanders and consumers of produce). The practice of pest management by the rational application of pesticides is supremely multi-disciplinary, combining many aspects of biology and chemistry with: agronomy, engineering, meteorology, socio-economics and public health, together with newer disciplines such as biotechnology and information science. Seed treatments can achieve exceptionally high efficiencies, in terms of effective dose-transfer to a crop. Pesticides are applied to the seed prior to planting, in the form of a seed treatment, or coating, to protect against soil-borne risks to the plant; additionally, these coatings can provide supplemental chemicals and nutrients designed to encourage growth. A typical seed coating can include a nutrient layer—containing nitrogen, phosphorus, and potassium, a rhizobial layer—containing symbiotic bacteria and other beneficial microorganisms, and a fungicide (or other chemical) layer to make the seed less vulnerable to pests. One of the most common forms of pesticide application, especially in conventional agriculture, is the use of mechanical sprayers. Hydraulic sprayers consists of a tank, a pump, a lance (for single nozzles) or boom, and a nozzle (or multiple nozzles). Sprayers convert a pesticide formulation, often containing a mixture of water (or another liquid chemical carrier, such as fertilizer) and chemical, into droplets, which can be large rain-type drops or tiny almost-invisible particles. This conversion is accomplished by forcing the spray mixture through a spray nozzle under pressure. The size of droplets can be altered through the use of different nozzle sizes, or by altering the pressure under which it is forced, or a combination of both. Large droplets have the advantage of being less susceptible to spray drift, but require more water per unit of land covered. Due to static electricity, small droplets are able to maximize contact with a target organism, but very still wind conditions are required. Traditional agricultural crop pesticides can either be applied pre-emergent or post-emergent, a term referring to the germination status of the plant. Pre-emergent pesticide application, in conventional agriculture, attempts to reduce competitive pressure on newly germinated plants by removing undesirable organisms and maximizing the amount of water, soil nutrients, and sunlight available for the crop. An example of pre-emergent pesticide application is atrazine application for corn. Similarly, glyphosate mixtures are often applied pre-emergent on agricultural fields to remove early-germinating weeds and prepare for subsequent crops. Pre-emergent application equipment often has large, wide tires designed to float on soft soil, minimizing both soil compaction and damage to planted (but not yet emerged) crops. A three-wheel application machine, such as the one pictured on the right, is designed so that tires do not follow the same path, minimizing the creation of ruts in the field and limiting sub-soil damage. Post-emergent pesticide application requires the use of specific chemicals chosen to minimize harm to the desirable target organism. An example is 2,4-Dichlorophenoxyacetic acid, which will injure broadleaf weeds (dicots) but leave behind grasses (monocots). Such a chemical has been used extensively on wheat crops, for example. A number of companies have also created genetically modified organisms that are resistant to various pesticides. Examples include glyphosate-resistant soybeans and Bt maize, which change the types of formulations involved in addressing post-emergent pesticide pressure. It is important to also note that even given appropriate chemical choices, high ambient temperatures or other environmental influences, can allow the non-targeted desirable organism to be damaged during application. As plants have already germinated, post-emergent pesticide application necessitates limited field contact in order to minimize losses due to crop and soil damage. Typical industrial application equipment will utilize very tall and narrow tires and combine this with a sprayer body which can be raised and lowered depending on crop height. These sprayers usually carry the label ‘high-clearance’ as they can rise over growing crops, although usually not much more than 1 or 2 meters high. In addition, these sprayers often have very wide booms in order to minimize the number of passes required over a field, again designed to limit crop damage and maximize efficiency. In industrial agriculture, spray booms 120 feet (40 meters) wide are not uncommon, especially in prairie agriculture with large, flat fields. Related to this, aerial pesticide application is a method of top dressing a pesticide to an emerged crop which eliminates physical contact with soil and crops. Air Blast sprayers, also known as air-assisted or mist sprayers, are often used for tall crops, such as tree fruit, where boom sprayers and aerial application would be ineffective. These types of sprayers can only be used where overspray—spray drift—is less of a concern, either through the choice of chemical which does not have undesirable effects on other desirable organisms, or by adequate buffer distance. These can be used for insects, weeds, and other pests to crops, humans, and animals. Air blast sprayers inject liquid into a fast-moving stream of air, breaking down large droplets into smaller particles by introducing a small amount of liquid into a fast-moving stream of air. Foggers fulfill a similar role to mist sprayers in producing particles of very small size, but use a different method. Whereas mist sprayers create a high-speed stream of air which can travel significant distances, foggers use a piston or bellows to create a stagnant area of pesticide that is often used for enclosed areas, such as houses and animal shelters. In order to better understand the cause of the spray inefficiency, it is useful to reflect on the implications of the large range of droplet sizes produced by typical (hydraulic) spray nozzles. This has long been recognized to be one of the most important concepts in spray application (e.g. Himel, 1969), bringing about enormous variations in the properties of droplets. Historically, dose-transfer to the biological target (i.e. the pest) has been shown to be inefficient. However, relating 'ideal' deposits with biological effect is fraught with difficulty), but in spite of Hislop’s misgivings about detail, there have been several demonstrations that massive amounts of pesticides are wasted by run-off from the crop and into the soil, in a process called endo-drift. This is a less familiar form of pesticide drift, with exo-drift causing much greater public concern. Pesticides are conventionally applied using hydraulic atomisers, either on hand-held sprayers or tractor booms, where formulations are mixed into high volumes of water.