RAMP3

1026856089ENSG00000122679ENSMUSG00000041046O60896Q9WUP1NM_005856NM_019511NP_005847NP_062384Receptor activity modifying protein 3, also known as RAMP3, is a human gene. Receptor activity modifying protein 3, also known as RAMP3, is a human gene. The protein encoded by this gene is a member of the RAMP family of single-transmembrane-domain proteins, called receptor (calcitonin) activity modifying proteins (RAMPs). RAMPs are type I transmembrane proteins with an extracellular N terminus and a cytoplasmic C terminus. RAMPs are required to transport calcitonin-receptor-like receptor (CRLR) to the plasma membrane. CRLR, a receptor with seven transmembrane domains, can function as either a calcitonin gene-related peptide (CGRP) receptor or an adrenomedullin receptor, depending on which members of the RAMP family are expressed. In humans and other mammals, there are 3 RAMPS, while in fish there are more, with sub-variants. In the presence of this (RAMP3) protein, CRLR functions as an adrenomedullin receptor with low affinity for CGRP. This article incorporates text from the United States National Library of Medicine, which is in the public domain.