In anatomy, rugae are a series of ridges produced by folding of the wall of an organ. Most commonly rugae refers to the gastric rugae of the internal surface of the stomach. In anatomy, rugae are a series of ridges produced by folding of the wall of an organ. Most commonly rugae refers to the gastric rugae of the internal surface of the stomach. The purpose of the gastric rugae is to allow for expansion of the stomach after the consumption of foods and liquids.