STUB1

4KBQ1027356424ENSG00000103266ENSMUSG00000039615Q9UNE7Q9WUD1NM_005861NM_001293197NM_019719NP_001280126NP_005852NP_062693STUB1 (STIP1 homology and U-Box containing protein 1) is a human gene that codes for the protein CHIP (C terminus of HSC70-Interacting Protein). 2c2l: CRYSTAL STRUCTURE OF THE CHIP U-BOX E3 UBIQUITIN LIGASE2c2v: CRYSTAL STRUCTURE OF THE CHIP-UBC13-UEV1A COMPLEX STUB1 (STIP1 homology and U-Box containing protein 1) is a human gene that codes for the protein CHIP (C terminus of HSC70-Interacting Protein). The CHIP protein encoded by this gene binds to and inhibits the ATPase activity of the chaperone proteins HSC70 and HSP70 and blocks the forward reaction of the HSC70-HSP70 substrate-binding cycle. In addition, CHIP possesses E3 ubiquitin ligase activity and promotes ubiquitylation, mainly of chaperone-bound misfolded proteins. CHIP enhances HSP70 induction during acute stress and also mediates its turnover during the stress recovery process. Hence CHIP appears to maintain protein homeostasis by controlling chaperone levels during stress and recovery. Mutations in STUB1 cause spinocerebellar ataxiatype 16. STUB1 has been shown to interact with: