GGA1

1J2J, 1JWF, 1JWG, 1NA8, 1NAF, 1NWM, 1O3X, 1OM9, 1OXZ, 1PY1, 1UJJ, 1UJK, 1X79, 2DWX, 2DWY, 3G2S, 3G2T, 3G2U, 3G2V, 3G2W26088106039ENSG00000100083ENSMUSG00000033128Q9UJY5Q8R0H9NM_001363771NM_145929NP_001001560NP_001166158NP_001166159NP_037497NP_001350700NP_666041ADP-ribosylation factor-binding protein GGA1 is a protein that in humans is encoded by the GGA1 gene.1j2j: Crystal structure of GGA1 GAT N-terminal region in complex with ARF1 GTP form1jwf: Crystal Structure of human GGA1 VHS domain.1jwg: VHS Domain of human GGA1 complexed with cation-independent M6PR C-terminal Peptide1na8: Crystal structure of ADP-ribosylation factor binding protein GGA11naf: crystal structure of the human GGA1 GAT domain1nwm: GAT domain of human GGA11o3x: Crystal structure of human GGA1 GAT domain1om9: Structure of the GGA1-appendage in complex with the p56 binding peptide1oxz: Crystal Structure of the Human GGA1 GAT domain1py1: Complex of GGA1-VHS domain and beta-secretase C-terminal phosphopeptide1ujj: VHS domain of human GGA1 complexed with C-terminal peptide from BACE1ujk: VHS domain of human GGA1 complexed with C-terminal phosphopeptide from BACE1x79: Crystal structure of human GGA1 GAT domain complexed with the GAT-binding domain of Rabaptin52dwx: Co-crystal Structure Analysis of GGA1-GAE with the WNSF motif2dwy: Crystal Structure Analysis of GGA1-GAE ADP-ribosylation factor-binding protein GGA1 is a protein that in humans is encoded by the GGA1 gene. This gene encodes a member of the Golgi-localized, gamma adaptin ear-containing, ARF-binding (GGA) protein family. Members of this family are ubiquitous coat proteins that regulate the trafficking of proteins between the trans-Golgi network and the lysosome. These proteins share an amino-terminal VHS domain which mediates sorting of the mannose 6-phosphate receptors at the trans-Golgi network. They also contain a carboxy-terminal region with homology to the ear domain of gamma-adaptins. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. GGA1 has been shown to interact with Sortilin 1, BACE2, RABEP1 and ARF3.