Bioelectromagnetics

Bioelectromagnetics, also known as bioelectromagnetism, is the study of the interaction between electromagnetic fields and biological entities. Areas of study include electrical or electromagnetic fields produced by living cells, tissues or organisms, including bioluminescent bacteria; for example, the cell membrane potential and the electric currents that flow in nerves and muscles, as a result of action potentials. Others include animal navigation utilizing the geomagnetic field; the effects of man-made sources of electromagnetic fields like mobile phones; and developing new therapies to treat various conditions. The term can also refer to the ability of living cells, tissues, and organisms to produce electrical fields and the response of cells to electromagnetic fields. Bioelectromagnetics, also known as bioelectromagnetism, is the study of the interaction between electromagnetic fields and biological entities. Areas of study include electrical or electromagnetic fields produced by living cells, tissues or organisms, including bioluminescent bacteria; for example, the cell membrane potential and the electric currents that flow in nerves and muscles, as a result of action potentials. Others include animal navigation utilizing the geomagnetic field; the effects of man-made sources of electromagnetic fields like mobile phones; and developing new therapies to treat various conditions. The term can also refer to the ability of living cells, tissues, and organisms to produce electrical fields and the response of cells to electromagnetic fields. Short-lived electrical events called action potentials occur in several types of animal cells which are called excitable cells, a category of cell include neurons, muscle cells, and endocrine cells, as well as in some plant cells. These action potentials are used to facilitate inter-cellular communication and activate intracellular processes. The physiological phenomena of action potentials are possible because voltage-gated ion channels allow the resting potential caused by electrochemical gradient on either side of a cell membrane to resolve. Bioelectromagnetism is studied primarily through the techniques of electrophysiology. In the late eighteenth century, the Italian physician and physicist Luigi Galvani first recorded the phenomenon while dissecting a frog at a table where he had been conducting experiments with static electricity. Galvani coined the term animal electricity to describe the phenomenon, while contemporaries labeled it galvanism. Galvani and contemporaries regarded muscle activation as resulting from an electrical fluid or substance in the nerves. Some usually aquatic animals, such as sharks, have acute bioelectric sensors providing a sense known as electroreception, while migratory birds navigate in part by orienteering with respect to the Earth's magnetic field. In an extreme application of electromagnetism, the electric eel is able to generate a large electric field outside its body used for hunting and self-defense through a dedicated electric organ. Most of the molecules in the human body interact weakly with electromagnetic fields in the radio frequency or extremely low frequency bands. One such interaction is absorption of energy from the fields, which can cause tissue to heat up; more intense fields will produce greater heating. This can lead to biological effects ranging from muscle relaxation (as produced by a diathermy device) to burns. Many nations and regulatory bodies like the International Commission on Non-Ionizing Radiation Protection have established safety guidelines to limit EMF exposure to a non-thermal level. This can be defined as either heating only to the point where the excess heat can be dissipated, or as a fixed increase in temperature not detectable with current instruments like 0.1 °C. However, biological effects have been shown to be present for these non-thermal exposures; Various mechanisms have been proposed to explain these, and there may be several mechanisms underlying the differing phenomena observed. Biological effects of weak electromagnetic fields are the subject of study in magnetobiology. Many behavioral effects at different intensities have been reported from exposure to magnetic fields, particularly with pulsed magnetic fields. The specific pulseform used appears to be an important factor for the behavioural effect seen; for example, a pulsed magnetic field originally designed for spectroscopic MRI, referred to as Low Field Magnetic Stimulation, was found to temporarily improve patient-reported mood in bipolar patients, while another MRI pulse had no effect. A whole-body exposure to a pulsed magnetic field was found to alter standing balance and pain perception in other studies. A strong changing magnetic field can induce electrical currents in conductive tissue such as the brain. Since the magnetic field penetrates tissue, it can be generated outside of the head to induce currents within, causing transcranial magnetic stimulation (TMS). These currents depolarize neurons in a selected part of the brain, leading to changes in the patterns of neural activity. In repeated pulse TMS therapy or rTMS, the presence of incompatible EEG electrodes can result in electrode heating and, in severe cases, skin burns. A number of scientists and clinicians are attempting to use TMS to replace electroconvulsive therapy (ECT) to treat disorders such as severe depression and hallucinations. Instead of one strong electric shock through the head as in ECT, a large number of relatively weak pulses are delivered in TMS therapy, typically at the rate of about 10 pulses per second. If very strong pulses at a rapid rate are delivered to the brain, the induced currents can cause convulsions much like in the original electroconvulsive therapy. Sometimes, this is done deliberately in order to treat depression, such as in ECT. While health effects from extremely low frequency (ELF) electric and magnetic fields (0 to 300 Hz) generated by power lines, and radio/microwave frequencies (RF) (10 MHz - 300 GHz) emitted by radio antennas and wireless networks have been well studied, the intermediate range (IR) used increasingly in modern telecommunications (300 Hz to 10 MHz) has been studied far less. Direct effects of electromagnetism on human health have been difficult to prove, and documented life-threatening interferences from electromagnetic fields are limited to medical devices such as pacemakers and other electronic implants. However, a number of studies have been conducted with artificial magnetic fields and electric fields to investigate their effects on cell metabolism, apoptosis, and tumor growth. Electromagnetic radiation in the intermediate frequency range has found a place in modern medical practice for the treatment of bone healing and for nerve stimulation and regeneration. It is also approved as cancer therapy in form of Tumor Treating Fields, using alternating electric fields in the frequency range of 100–300 kHz. Since some of these methods involve magnetic fields that invoke electric currents in biological tissues and others only involve electric fields, they are strictly speaking electrotherapies albeit their application modi with modern electronic equipment have placed them in the category of bioelectromagnetic interactions.