Alloantigen recognition

Alloantigen recognition is the mechanism by which T cells may recognize alloantigens and lead to transplant rejection after an organ transplant. It is broadly divided into direct and indirect alloantigen recognition. Alloantigen recognition is the mechanism by which T cells may recognize alloantigens and lead to transplant rejection after an organ transplant. It is broadly divided into direct and indirect alloantigen recognition. Donor tissue dendritic cells migrate to lymph nodes, stimulating a measurable percentage of recipient T cells. The host T cells in the lymph node recognize either the allograft HLA or an associated bound peptide.