Cofilin 1

4BEX, 1Q8G, 1Q8X, 3J0S, 5HVK, 5L6W107212631ENSG00000172757ENSMUSG00000056201P23528P18760NM_005507NM_007687NP_005498NP_031713Cofilin 1 (non-muscle; n-cofilin), also known as CFL1, is a human gene, part of the ADF/cofilin family.1q8g: NMR structure of human Cofilin1q8x: NMR structure of human cofilin Cofilin 1 (non-muscle; n-cofilin), also known as CFL1, is a human gene, part of the ADF/cofilin family. Cofilin is a widely distributed intracellular actin-modulating protein that binds and depolymerizes filamentous F-actin and inhibits the polymerization of monomeric G-actin in a pH-dependent manner. It is involved in the translocation of actin-cofilin complex from cytoplasm to nucleus. One group reports that reelin signaling leads to serine3-phosphorylation of cofilin-1, and this interaction may play a role in the reelin-related regulation of neuronal migration. Cofilin 1 has been shown to interact with HSPH1 and LIMK1.