FOXA2

317015376ENSG00000125798ENSMUSG00000037025Q9Y261P35583NM_021784NM_153675NM_001291065NM_001291067NM_010446NP_068556NP_710141NP_001277994NP_001277996NP_034576Hepatocyte nuclear factor 3-beta (HNF-3B), also known as forkhead box protein A2 (FOXA2) or transcription factor 3B (TCF-3B) is a protein that in humans is encoded by the FOXA2 gene. Hepatocyte nuclear factor 3-beta (HNF-3B), also known as forkhead box protein A2 (FOXA2) or transcription factor 3B (TCF-3B) is a protein that in humans is encoded by the FOXA2 gene. Forkhead box protein A2 is a member of the forkhead class of DNA-binding proteins. These hepatocyte nuclear factors are transcriptional activators for liver-specific genes such as albumin and transthyretin, and they also interact with chromatin. Similar family members in mice have roles in the regulation of metabolism and in the differentiation of the pancreas and liver. This gene has been linked to sporadic cases of maturity onset diabetes of the young. Transcript variants encoding different isoforms have been identified for this gene. This article incorporates text from the United States National Library of Medicine, which is in the public domain.