AKT2

1GZK, 1GZN, 1GZO, 1MRV, 1MRY, 1O6K, 1O6L, 1P6S, 2JDO, 2JDR, 2UW9, 2X39, 2XH5, 3D0E, 3E87, 3E88, 3E8D20811652ENSG00000105221ENSMUSG00000004056P31751Q60823NM_001243027NM_001243028NM_001626NM_001330511NM_001110208NM_007434NM_001331108NM_001331109NP_001229956NP_001229957NP_001317440NP_001617NP_001103678NP_001318037NP_001318038NP_031460RAC-beta serine/threonine-protein kinase is an enzyme that in humans is encoded by the AKT2 gene.1gzk: MOLECULAR MECHANISM FOR THE REGULATION OF PROTEIN KINASE B/ AKT BY HYDROPHOBIC MOTIF PHOSPHORYLATION1gzn: STRUCTURE OF PKB KINASE DOMAIN1gzo: STRUCTURE OF PROTEIN KINASE B UNPHOSPHORYLATED1mrv: crystal structure of an inactive Akt2 kinase domain1mry: crystal structure of an inactive akt2 kinase domain1o6k: STRUCTURE OF ACTIVATED FORM OF PKB KINASE DOMAIN S474D WITH GSK3 PEPTIDE AND AMP-PNP1o6l: CRYSTAL STRUCTURE OF AN ACTIVATED AKT/PROTEIN KINASE B (PKB-PIF CHIMERA) TERNARY COMPLEX WITH AMP-PNP AND GSK3 PEPTIDE1p6s: Solution Structure of the Pleckstrin Homology Domain of Human Protein Kinase B beta (Pkb/Akt)2jdo: STRUCTURE OF PKB-BETA (AKT2) COMPLEXED WITH ISOQUINOLINE-5-SULFONIC ACID (2-(2-(4-CHLOROBENZYLOXY) ETHYLAMINO)ETHYL) AMIDE2jdr: STRUCTURE OF PKB-BETA (AKT2) COMPLEXED WITH THE INHIBITOR A-4436542uw9: STRUCTURE OF PKB-BETA (AKT2) COMPLEXED WITH 4-(4-CHLORO-PHENYL)-4-(4-(1H-PYRAZOL-4-YL)-PHENYL)-PIPERIDINE RAC-beta serine/threonine-protein kinase is an enzyme that in humans is encoded by the AKT2 gene. This gene is a putative oncogene encoding a protein belonging to the AKT subfamily of serine/threonine kinases that contain SH2-like (Src homology 2-like) domains. The encoded protein is a general protein kinase capable of phosphorylating several known proteins. The gene was shown to be amplified and overexpressed in 2 of 8 ovarian carcinoma cell lines and 2 of 15 primary ovarian tumors. Overexpression contributes to the malignant phenotype of a subset of human ductal pancreatic cancers. Mice lacking Akt2 have a normal body mass, but display a profound diabetic phenotype, indicating that Akt2 plays a key role in signal transduction downstream of the insulin receptor. Mice lacking Akt2 show worse outcome in breast cancer initiated by the large T antigen as well as the neu oncogene. AKT2 has been shown to interact with: