Multiple familial trichoepithelioma is a cutaneous condition characterized by multiple cystic and solid nodules appearing on the face.:672 Multiple familial trichoepithelioma is a cutaneous condition characterized by multiple cystic and solid nodules appearing on the face.:672 The classification of this syndrome is difficult. Three conditions are known to be caused by mutations in the CYLD gene: Brooke-Spiegler syndrome, multiple familial trichoepithelioma, and familial cylindromatosis. Clinically, these are distinct, but appear to arise from mutations in the same gene.