HDAC4

2H8N, 2O94, 2VQJ, 2VQM, 2VQO, 2VQQ, 2VQV, 2VQW, 3UXG, 3UZD, 3V31, 4CBT, 4CBY, 5A2S9759208727ENSG00000068024ENSMUSG00000026313P56524Q6NZM9NM_006037NM_207225NP_006028NP_997108Histone deacetylase 4, also known as HDAC4, is a protein that in humans is encoded by the HDAC4 gene.2h8n: Structure of a glutamine-rich domain from histone deacetylase 42o94: The 97H/F mutant Structure of a glutamine-rich domain from histone deacetylase 4 Histone deacetylase 4, also known as HDAC4, is a protein that in humans is encoded by the HDAC4 gene. Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class II of the histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. This protein does not bind DNA directly but through transcription factors MEF2C and MEF2D. It seems to interact in a multiprotein complex with RbAp48 and HDAC3. Furthermore, HDAC4 is required for TGFbeta1-induced myofibroblastic differentiation. Studies have shown that HDAC4 regulates bone and muscle development. Harvard University researchers also concluded that it promotes healthy vision: Reduced levels of the protein led to the death of the rod photoreceptors and bipolar cells in the retinas of mice. HDAC4 has been shown to interact with: This article incorporates text from the United States National Library of Medicine, which is in the public domain.