Passerini reaction

The Passerini reaction is a chemical reaction involving an isocyanide, an aldehyde (or ketone), and a carboxylic acid to form a α-acyloxy amide. The Passerini reaction is a chemical reaction involving an isocyanide, an aldehyde (or ketone), and a carboxylic acid to form a α-acyloxy amide. This organic reaction was discovered by Mario Passerini in 1921 in Florence, Italy. It is the first isocyanide based multi-component reaction developed, and currently plays a central role in combinatorial chemistry. Recently, Denmark et al. have developed an enantioselective catalyst for asymmetric Passerini reactions.