BMPR1A

3QB4, 1ES7, 1REW, 2GOO, 2H62, 2H64, 2K3G, 2QJ9, 2QJA, 2QJB, 3NH765712166ENSG00000107779ENSMUSG00000021796P36894P36895NM_004329NM_009758NP_004320NP_033888The bone morphogenetic protein receptor, type IA also known as BMPR1A is a protein which in humans is encoded by the BMPR1A gene. BMPR1A has also been designated as CD292 (cluster of differentiation 292).1es7: COMPLEX BETWEEN BMP-2 AND TWO BMP RECEPTOR IA ECTODOMAINS1rew: Structural refinement of the complex of bone morphogenetic protein 2 and its type IA receptor2goo: Ternary Complex of BMP-2 bound to BMPR-Ia-ECD and ActRII-ECD2h62: Crystal structure of a ternary ligand-receptor complex of BMP-22h64: Crystal structure of a ternary ligand-receptor complex of BMP-2 The bone morphogenetic protein receptor, type IA also known as BMPR1A is a protein which in humans is encoded by the BMPR1A gene. BMPR1A has also been designated as CD292 (cluster of differentiation 292). The bone morphogenetic protein (BMP) receptors are a family of transmembrane serine/threonine kinases that include the type I receptors BMPR1A (this protein) and BMPR1B and the type II receptor BMPR2. These receptors are also closely related to the activin receptors, ACVR1 and ACVR2. The ligands of these receptors are members of the TGF beta superfamily. TGF-betas and activins transduce their signals through the formation of heteromeric complexes with 2 different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding. BMP's repress WNT signaling to maintain stable stem cell populations. BMPR1A null mice died at embryonic day 8.0 without mesoderm specification, demonstrating its vital role in gastrulation. It has been demonstrated in experiments using dominant negative BMPR1A chick embryos that BMPR1A plays a role in apoptosis and adipocyte development. Using constitutively active forms of BMR1A it has been shown that it plays a role in cell differentiation. Signals tranduced by the BMPR1A receptor are not essential for osteoblast formation or proliferation; however, BMPR1A is necessary for the extracellular matrix deposition by osteoblasts. In the chick embryo, BMPR1A receptors are found in low levels in limb bud mesenchyme, a differing location to BMPR1B, supporting the differing roles they play in osteogenesis. BMPR1A, SMAD4 and PTEN are responsible for juvenile polyposis syndrome, juvenile intestinal polyposis and Cowden's disease. BMPR1A has been shown to interact with: