IRAK1

365416179ENSG00000184216ENSMUSG00000031392P51617Q62406NM_001025242NM_001025243NM_001569NM_001177973NM_001177974NM_001177975NM_001177976NM_008363NP_001020413NP_001020414NP_001560NP_001171444NP_001171445NP_001171446NP_001171447NP_032389Interleukin-1 receptor-associated kinase 1 is an enzyme that in humans is encoded by the IRAK1 gene. Interleukin-1 receptor-associated kinase 1 is an enzyme that in humans is encoded by the IRAK1 gene. This gene encodes the interleukin-1 receptor-associated kinase 1, one of two putative serine/threonine kinases that become associated with the interleukin-1 receptor (IL1R) upon stimulation. This gene is partially responsible for IL1-induced upregulation of the transcription factor NF-kappa B. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. IRAK1 has been shown to interact with: IRAK1 signaling is involved in rheumatoid arthritis.