N2a cell

N2a cells (also known as Neuro2a cells) are a fast-growing mouse neuroblastoma cell line. N2a cells (also known as Neuro2a cells) are a fast-growing mouse neuroblastoma cell line. Originating from a mouse, the N2a cell line has a neuronal and amoeboid stem cell morphology, allowing it to differentiate in response to environmental factors. The differentiated cells have many properties of neurons, including neurofilaments. The cells, due to passaging since initial collection, can exhibit responses to toxins that differ from those of neuronal cells in a live organism. Synthesizing large amounts of microtubules, N2a cells are susceptible to viruses (such as herpes simplex and poliovirus) that can alter cell morphology and physiology. N2a cells have been used to study neurite outgrowth, neurotoxicity, Alzheimer's disease,, asymmetric division of mammalian cell lines, adenoviral transduction, and the diagnosing of rabies.