VAV1

2CRH, 2LCT, 2MC1, 2ROR, 3BJI, 3KY9740922324ENSG00000141968ENSMUSG00000034116P15498P27870NM_001258206NM_001258207NM_005428NM_001163815NM_001163816NM_011691NP_001245135NP_001245136NP_005419NP_001157287NP_001157288NP_035821Proto-oncogene vav is a protein that in humans is encoded by the VAV1 gene.1k1z: Solution structure of N-terminal SH3 domain mutant(P33G) of murine Vav Proto-oncogene vav is a protein that in humans is encoded by the VAV1 gene. The protein encoded by this proto-oncogene is a member of the Dbl family of guanine nucleotide exchange factors (GEF) for the Rho family of GTP binding proteins. The protein is important in hematopoiesis, playing a role in T-cell and B-cell development and activation. This particular GEF has been identified as the specific binding partner of Nef proteins from HIV-1. Coexpression and binding of these partners initiates profound morphological changes, cytoskeletal rearrangements and the JNK/SAPK signaling cascade, leading to increased levels of viral transcription and replication. VAV1 has been shown to interact with: