BUB1B

2WVI, 3SI5, 4GGD, 5JJA70112236ENSG00000156970ENSMUSG00000040084O60566Q9Z1S0NM_001211NM_009773NP_001202NP_033903Mitotic checkpoint serine/threonine-protein kinase BUB1 beta is an enzyme that in humans is encoded by the BUB1B gene. Mitotic checkpoint serine/threonine-protein kinase BUB1 beta is an enzyme that in humans is encoded by the BUB1B gene. This gene encodes a kinase involved in spindle checkpoint function and chromosome segregation. The protein has been localized to the kinetochore and plays a role in the inhibition of the anaphase-promoting complex/cyclosome (APC/C), delaying the onset of anaphase and ensuring proper chromosome segregation. Impaired spindle checkpoint function has been found in many forms of cancer. Increased expression of BubR1 in mice extends a healthy lifespan. BUB1B has been shown to interact with: