Allotopic expression

Gensight Biologics are currently pursuing a clinical program of expressing the ND4 gene in the nucleus to prevent retinal disease. The SENS Research Foundation recently reported success in expressing the ATP6 gene allotopically in vitro. As of 6 September 2016 and as a result of funds raised at lifespan.io SENS Research Foundation showed ATP6 and ATP8 could be successfully expressed and their published research appears in Nucleic Acids Research providing proof of concept for the MitoSENS repair approach for repairing age related damage.