ABL2

2ECD, 2KK1, 2XYN, 3GVU, 3HMI, 3ULR, 4EIH2711352ENSG00000143322ENSMUSG00000026596P42684Q4JIM5NM_001168239NM_005158NM_007314NM_001136104NM_009595NP_001161711NP_005149NP_009298n/aTyrosine-protein kinase ABL2 also known as Abelson-related gene (Arg) is an enzyme that in humans is encoded by the ABL2 gene.1ab2: THREE-DIMENSIONAL SOLUTION STRUCTURE OF THE SRC HOMOLOGY 2 DOMAIN OF C-ABL1abo: CRYSTAL STRUCTURE OF THE COMPLEX OF THE ABL TYROSINE KINASE SH3 DOMAIN WITH 3BP-1 SYNTHETIC PEPTIDE1abq: CRYSTAL STRUCTURE OF THE UNLIGANDED ABL TYROSINE KINASE SH3 DOMAIN1bbz: CRYSTAL STRUCTURE OF THE ABL-SH3 DOMAIN COMPLEXED WITH A DESIGNED HIGH-AFFINITY PEPTIDE LIGAND: IMPLICATIONS FOR SH3-LIGAND INTERACTIONS1fpu: CRYSTAL STRUCTURE OF ABL KINASE DOMAIN IN COMPLEX WITH A SMALL MOLECULE INHIBITOR1iep: CRYSTAL STRUCTURE OF THE C-ABL KINASE DOMAIN IN COMPLEX WITH STI-571.1ju5: Ternary complex of an Crk SH2 domain, Crk-derived phophopeptide, and Abl SH3 domain by NMR spectroscopy1m52: Crystal Structure of the c-Abl Kinase domain in complex with PD1739551opj: Structural basis for the auto-inhibition of c-Abl tyrosine kinase2e2b: Crystal structure of the c-Abl kinase domain in complex with INNO-4062f4j: Structure of the Kinase Domain of an Imatinib-Resistant Abl Mutant in Complex with the Aurora Kinase Inhibitor VX-6802g1t: A Src-like Inactive Conformation in the Abl Tyrosine Kinase Domain2g2f: A Src-like Inactive Conformation in the Abl Tyrosine Kinase Domain2g2h: A Src-like Inactive Conformation in the Abl Tyrosine Kinase Domain2g2i: A Src-like Inactive Conformation in the Abl Tyrosine Kinase Domain2gqg: X-ray Crystal Structure of Dasatinib (BMS-354825) Bound to Activated ABL Kinase Domain2hiw: Crystal Structure of Inactive Conformation Abl Kinase Catalytic Domain Complexed with Type II Inhibitor2hyy: Human Abl kinase domain in complex with imatinib (STI571, Glivec)2hz0: Abl kinase domain in complex with NVP-AEG0822hz4: Abl kinase domain unligated and in complex with tetrahydrostaurosporine2hzi: Abl kinase domain in complex with PD1809702hzn: Abl kinase domain in complex with NVP-AFG210 Tyrosine-protein kinase ABL2 also known as Abelson-related gene (Arg) is an enzyme that in humans is encoded by the ABL2 gene. ABL2 is a cytoplasmic tyrosine kinase which is closely related to but distinct from ABL1. The similarity of the proteins includes the tyrosine kinase domains and extends amino-terminal to include the SH2 and SH3 domains. ABL2 is expressed in both normal and tumor cells. The expression of ABL2 gene is higher in KRAS mutant non-small cell lung cancer. The ABL2 gene product is expressed as two variants bearing different amino termini, both approximately 12-kb in length. ABL2 has been shown to interact with three proteins: Abl gene, catalase, and SORBS2. The protein Abl gene is also known as abelson murine leukemia viral oncogene homolog 1 and is a protein that is encoded by the human ABL1 gene. Catalase is a common enzyme that catalyzes the decomposition of hydrogen peroxide to water and oxygen. SORBS2 is also known as Sorbin and SH3 domain-containing protein 2 and is a protein encoded by the SORBS2 gene in humans.