SIAH1

2A25, 4C9Z, 4CA1, 4I7B, 4I7C, 4I7D, 4X3G647720437ENSG00000196470ENSMUSG00000036840Q8IUQ4P61092NM_001006610NM_003031NM_009172NP_001006611NP_003022NP_033198E3 ubiquitin-protein ligase SIAH1 is an enzyme that in humans is encoded by the SIAH1 gene.1k2f: siah, Seven In Absentia Homolog2a25: Crystal structure of Siah1 SBD bound to the peptide EKPAAVVAPITTG from SIP2an6: Protein-peptide complex E3 ubiquitin-protein ligase SIAH1 is an enzyme that in humans is encoded by the SIAH1 gene. This gene encodes for a polypeptide structure that is a member of the seven in absentia homolog (SIAH) family. The protein is an E3 ligase and is involved in ubiquitination and proteasome-mediated degradation of specific proteins. The activity of this ubiquitin ligase has been implicated in the development of certain forms of Parkinson's disease, the regulation of the cellular response to hypoxia and induction of apoptosis. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized. SIAH1 has been shown to interact with: