Congenital insensitivity to pain with anhidrosis

Congenital insensitivity to pain with anhidrosis (CIPA) is rare autosomal recessive disorder of the nervous system which prevents the feeling of pain or temperature, and prevents a person from sweating. Mental retardation is common. CIPA is the fourth type of hereditary sensory and autonomic neuropathy (HSAN), and is also known as HSAN IV.EDAR (EDAR hypohidrotic ectodermal dysplasia) Congenital insensitivity to pain with anhidrosis (CIPA) is rare autosomal recessive disorder of the nervous system which prevents the feeling of pain or temperature, and prevents a person from sweating. Mental retardation is common. CIPA is the fourth type of hereditary sensory and autonomic neuropathy (HSAN), and is also known as HSAN IV. Signs of CIPA are present from infancy. Infants may present with seizures related to hyperthermia. Because people with this condition are unable to sweat, they are unable to regulate their body temperature. Those affected are unable to feel pain and temperature, but retain the ability to feel touch. Mental retardation is often present. Lack of pain puts those with CIPA at a high risk for accidental self-mutilation. Corneal ulceration occurs due to lack of protective impulses. Joint and bone problems are common due to repeated injuries, and wounds heal poorly.