DNA damage-inducible transcript 3

164913198ENSG00000175197ENSMUSG00000025408P35638P35639NM_004083NM_001290183NM_007837NP_004074NP_001277112NP_031863DNA damage-inducible transcript 3, also known as C/EBP homologous protein (CHOP), is a pro-apoptotic transcription factor that is encoded by the DDIT3 gene. DNA damage-inducible transcript 3, also known as C/EBP homologous protein (CHOP), is a pro-apoptotic transcription factor that is encoded by the DDIT3 gene. DNA damage-inducible transcript 3 has been shown to interact with : During endoplasmic reticulum stress (such as occurs in beta cells of the pancreas or in macrophages causing atherosclerosis), CHOP can induce activation of Ero1, causing calcium release from the endoplasmic reticulum into the cytoplasm, resulting in apoptosis. CHOP also induces apoptosis during endoplasmic reticulum stress by activating growth arrest and DNA damage-inducible protein GADD34. Mutations or fusions of CHOP (e.g. with FUS to form FUS-CHOP) can cause Myxoid liposarcoma. This article incorporates text from the United States National Library of Medicine, which is in the public domain.