Eukaryotic translation initiation factor 4 gamma

1LJ2, 1UG3, 2W97, 4AZA, 4F021981208643ENSG00000114867ENSMUSG00000045983Q04637Q6NZJ6NM_182917NM_198241NM_198242NM_001005331NM_145941NM_001304432NP_937884NP_937885NP_937887NP_001291361NP_666053Eukaryotic translation initiation factor 4 gamma 1 is a protein that in humans is encoded by the EIF4G1 gene.1ug3: C-terminal portion of human eIF4GI Eukaryotic translation initiation factor 4 gamma 1 is a protein that in humans is encoded by the EIF4G1 gene. The protein encoded by this gene is a component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure, and recruitment of mRNA to the ribosome. Alternative splicing results in five transcript variants encoding four distinct isoforms. eIF4G serves as a scaffold, interacting with mRNA and the other components of the eIF4F complex, as well as the PABP and eIF3. Eukaryotic translation initiation factor 4 gamma has been shown to interact with MKNK1, EIF4A1, EIF4E, MKNK2 and PABPC1.