ABCD3

582519299ENSG00000117528ENSMUSG00000028127P28288P55096NM_001122674NM_002858NM_008991NM_001355756NP_001116146NP_002849NP_033017NP_001342685ATP-binding cassette sub-family D member 3 is a protein that in humans is encoded by the ABCD3 gene. ATP-binding cassette sub-family D member 3 is a protein that in humans is encoded by the ABCD3 gene. The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ALD subfamily, which is involved in peroxisomal import of fatty acids and/or fatty acyl-CoAs in the organelle. All known peroxisomal ABC transporters are half transporters which require a partner half transporter molecule to form a functional homodimeric or heterodimeric transporter. This peroxisomal membrane protein likely plays an important role in peroxisome biogenesis. Mutations have been associated with some forms of Zellweger syndrome, a heterogeneous group of peroxisome assembly disorders. ABCD3 has been shown to interact with PEX19. This article incorporates text from the United States National Library of Medicine, which is in the public domain.