RAS p21 protein activator 1

1WER, 1WQ1, 2GQI, 2J05, 2J06, 2M51, 4FSS, 2GSB5921218397ENSG00000145715ENSMUSG00000021549P20936E9PYG6NM_002890NM_022650NM_145452NP_002881NP_072179NP_663427RAS p21 protein activator 1 or RasGAP (Ras GTPase activating protein), also known as RASA1, is a 120-kDa cytosolic human protein that provides two principal activities:}}1wer: RAS-GTPASE-ACTIVATING DOMAIN OF HUMAN P120GAP1wq1: RAS-RASGAP COMPLEX2gqi: Solution structure of the SH3 domain of human Ras GTPase-activating protein 12gsb: Solution structure of the second SH2 domain of human Ras GTPase-activating protein 12j05: CRYSTAL STRUCTURE OF THE RASGAP SH3 DOMAIN AT 1.5 ANGSTROM RESOLUTION2j06: CRYSTAL STRUCTURE OF THE RASGAP SH3 DOMAIN AT 1.8 ANGSTROM RESOLUTION RAS p21 protein activator 1 or RasGAP (Ras GTPase activating protein), also known as RASA1, is a 120-kDa cytosolic human protein that provides two principal activities: The protein encoded by this gene is located in the cytoplasm and is part of the GAP1 family of GTPase-activating proteins. The gene product stimulates the GTPase activity of normal RAS p21 but not its oncogenic counterpart. Acting as a suppressor of RAS function, the protein enhances the weak intrinsic GTPase activity of RAS proteins resulting in the inactive GDP-bound form of RAS, thereby allowing control of cellular proliferation and differentiation. Mutations leading to changes in the binding sites of either protein are associated with basal cell carcinomas. Alternative splicing results in two isoforms where the shorter isoform, lacking the N-terminal hydrophobic region but retaining the same activity, appears to be abundantly expressed in placental but not adult tissues. RasGAP contains one SH3 domain and two SH2 domains, a PH domain, a C2 domain, and a GAP domain. RAS p21 protein activator 1 has been shown to interact with: The mRNA can interact with Mir-132 microRNA; this process is linked to angiogenesis. RASA1 gene variant database