SAR1B

5112866397ENSG00000152700ENSMUSG00000020386Q9Y6B6Q9CQC9NM_016103NM_001033503NM_025535NP_001028675NP_057187NP_079811SAR1 gene homolog B (S. cerevisiae), also known as SAR1B, is a protein which in humans is encoded by the SAR1B gene.1f6b: CRYSTAL STRUCTURE OF SAR1-GDP COMPLEX2fa9: The crystal structure of Sar1-GDP provides insight into the coat-controlled GTP hydrolysis in the disassembly of COP II2fmx: An open conformation of switch I revealed by Sar1-GDP crystal structure at low Mg(2+) SAR1 gene homolog B (S. cerevisiae), also known as SAR1B, is a protein which in humans is encoded by the SAR1B gene. SAR1B belongs to the Sar1-ADP ribosylation factor family of small GTPases, which govern the intracellular trafficking of proteins in coat protein (COP)-coated vesicles. Mutations in the SAR1B gene are associated with chylomicron retention disease (also known as Anderson disease) which is an autosomal recessive disorder of severe fat malabsorption.