HDAC7

3C0Y, 3C0Z, 3C10, 3ZNR, 3ZNS5156456233ENSG00000061273ENSMUSG00000022475Q8WUI4Q8C2B3NM_001098416NM_001308090NM_015401NM_016596NM_001368046NM_001204280NM_001204281NM_019572NP_001091886NP_001295019NP_056216NP_001354975NP_001191209NP_001191210NP_062518Histone deacetylase 7 is an enzyme that in humans is encoded by the HDAC7 gene. Histone deacetylase 7 is an enzyme that in humans is encoded by the HDAC7 gene. Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene has sequence homology to members of the histone deacetylase family. This gene is orthologous to mouse HDAC7 gene whose protein promotes repression mediated via transcriptional corepressor SMRT. Multiple alternatively spliced transcript variants encoding several isoforms have been found for this gene. HDAC7 has both structural and functional similarity to HDACs 4, 5, and 9, as these four HDACs make up the Class IIa of HDACs in higher eukaryotes. Class IIa HDACs are phosphorylated by calcium/calmodulin dependent-kindase (CaMK) and protein kinase D (PKD) in response to kinase-dependent signaling. HDAC7 possesses little intrinsic deacetylase activity and therefore requires association with the class I HDAC, HDAC3 in order to suppress gene expression. It has been demonstrated through crystal structures of the human HDAC7 that the catalytic domain of HDAC7 has an additional class IIa HDAC-specific zinc binding motif adjacent to the active site. This is most likely to allow for substrate recognition and protein-protein interactions that are necessary for class IIa HDAC enzymes.