SYT1

2K45, 2K4A, 2K8M, 2KI6, 2LHA, 2N1T, 2R83, 3F00, 3F01, 3F04, 3F05, 4ISQ, 4V11685720979ENSG00000067715ENSMUSG00000035864P21579P46096NM_001135805NM_001135806NM_001291901NM_005639NM_001358503NM_001358504NM_001358506NP_001129277NP_001129278NP_001278830NP_005630NP_001345432NP_001345433NP_001345435Synaptotagmin-1 is a protein that in humans is encoded by the SYT1 gene.1byn: SOLUTION STRUCTURE OF THE CALCIUM-BOUND FIRST C2-DOMAIN OF SYNAPTOTAGMIN I1k5w: THREE-DIMENSIONAL STRUCTURE OF THE SYNAPTOTAGMIN 1 C2B-DOMAIN: SYNAPTOTAGMIN 1 AS A PHOSPHOLIPID BINDING MACHINE1rsy: STRUCTURE OF THE FIRST C2-DOMAIN OF SYNAPTOTAGMIN I: A NOVEL CA2+(SLASH)PHOSPHOLIPID BINDING FOLD1tjm: Crystallographic Identification of Sr2+ Coordination Site in Synaptotagmin I C2B Domain1tjx: Crystallographic Identification of Ca2+ Coordination Sites in Synaptotagmin I C2B Domain1uov: CALCIUM BINDING DOMAIN C2B1uow: CALCIUM BINDING DOMAIN C2B Synaptotagmin-1 is a protein that in humans is encoded by the SYT1 gene. The synaptotagmins are integral membrane proteins of synaptic vesicles thought to serve as sensors for calcium ions (Ca2+)in the process of vesicular trafficking and exocytosis. Calcium ion binding to synaptotagmin I participates in triggering neurotransmitter release at the synapse (Fernandez-Chacon et al., 2001). SYT1 is the master switch responsible for allowing the human brain to release neurotransmitters. SYT1 senses calcium ion concentrations as low as 10 ppm and subsequently signals the SNARE complex to open fusion pores. SYT1 has been shown to interact with SNAP-25, STX1A and S100A13.