Gastricsin

1AVF, 1HTR5225109820ENSG00000096088ENSMUSG00000023987P20142Q9D7R7NM_002630NM_001166424NM_025973NP_001159896NP_002621NP_080249Gastricsin also known as pepsinogen C is an enzyme that in humans is encoded by the PGC gene.1avf: ACTIVATION INTERMEDIATE 2 OF HUMAN GASTRICSIN FROM HUMAN STOMACH1htr: CRYSTAL AND MOLECULAR STRUCTURES OF HUMAN PROGASTRICSIN AT 1.62 ANGSTROMS RESOLUTION Gastricsin also known as pepsinogen C is an enzyme that in humans is encoded by the PGC gene. Gastricsin is an aspartic proteinase that belongs to the peptidase family A1. The encoded protein is a digestive enzyme that is produced in the stomach and constitutes a major component of the gastric mucosa. This protein is also secreted into the serum. This protein is synthesized as an inactive zymogen that includes a highly basic prosegment. This enzyme is converted into its active mature form at low pH by sequential cleavage of the prosegment that is carried out by the enzyme itself. Polymorphisms in this gene are associated with susceptibility to gastric cancers. Serum levels of this enzyme are used as a biomarker for certain gastric diseases including Helicobacter pylori related gastritis. This article incorporates text from the United States National Library of Medicine, which is in the public domain.